[表皮生长因子诱导A-431细胞中小RNA及小核糖核蛋白表达的特异性变化]
[The epidermal growth factor induces specific changes in the expression of small RNA and of the set of small RNP in A-431 cells].
作者信息
Konstantinova I M, Kulichkova V A, Turoverova L V, Petukhova O A, Kozhukharova I V, Teslenko L A
出版信息
Tsitologiia. 1994;36(2):174-81.
Specific small ribonucleoprotein (alpha-RNP) complexes have been identified and characterized in the human epidermal carcinoma A-431 cells. The alpha-RNP complexes contain Alu-homologous small RNA, along with other small antisense RNA species. The epidermal growth factor (EGF) has been shown to induce selective specific changes in the expression of the small alpha-RNAs, the expression of the Alu-like RNA being repressed. Specific changes in the protein composition of the alpha-RNP complexes have been detected under the influence of EGF.
在人表皮癌A - 431细胞中已鉴定并表征了特定的小核糖核蛋白（α - RNP）复合物。α - RNP复合物包含与Alu同源的小RNA，以及其他小反义RNA种类。已证明表皮生长因子（EGF）可诱导小α - RNAs表达的选择性特异性变化，Alu样RNA的表达受到抑制。在EGF的影响下，已检测到α - RNP复合物蛋白质组成的特异性变化。
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