[K-562细胞中一类含反义RNA的新型小核糖核蛋白（α-核糖核蛋白）。I. 其在红系分化过程中的特征及变化]
[A new class of small RNP (alpha-RNP) containing antisense RNA in K-562 cells. I. Their characteristics and changes during erythroid differentiation].
作者信息
Konstantinova I M, Petukhova O A, Kulikova V A, Turoverova L V, Volkova I V, Ignatova T N, Kozhukharova I V, Ermolaeva Iu B, Gauze L N
出版信息
Ontogenez. 1996 May-Jun;27(3):186-92.
A new class of small RNP (alpha-RNP) has been detected and identified in nuclei and cytoplasm of A-562 erythroid leukemia cell line; these RNPs have a characteristic spectrum of proteins containing conservative and specific components and a special RNA component, which contains a small antisense component (alpha-RNA), a homolog of short dispersed Alu repeats. alpha-RNP is highly stable, tightly associated with chromatin in the nucleus, and is found in the free state in cytoplasm. The composition of nuclear and cytoplasmic alpha-RNP differ and have a specific pattern of changes in response to dimethylsulfoxide, an agent causing differentiation.
在A-562红白血病细胞系的细胞核和细胞质中已检测并鉴定出一类新型小核糖核蛋白（α-核糖核蛋白）；这些核糖核蛋白具有含保守和特定成分的特征性蛋白质谱以及一种特殊的RNA成分，该RNA成分包含一个小反义成分（α-RNA），即短分散Alu重复序列的同源物。α-核糖核蛋白高度稳定，在细胞核中与染色质紧密结合，并在细胞质中以游离状态存在。细胞核和细胞质中的α-核糖核蛋白组成不同，且对导致分化的二甲基亚砜有特定的变化模式。
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