Infante P F, Schuman L D, Dement J, Huff J
Occupational and Environmental Medicine, Duke University Medical Center, Durham, NC.
Am J Ind Med. 1994 Oct;26(4):559-84. doi: 10.1002/ajim.4700260413.
Some argue that fibrous glass (glass wool) should not be considered as a likely human carcinogen and hence should not be listed in the Seventh Annual Report on Carcinogens (ARC) prepared by the National Toxicology Program (NTP) and mandated by the U.S. Congress. In examining this issue, data from both laboratory experiments (animal studies) and epidemiologic studies (human data) are reviewed with the results evaluated according to the criteria established by the International Agency for Research on Cancer (IARC) and adopted in slightly modified form by the NTP for classifying substances as human carcinogens or likely human carcinogens. From our comprehensive review of the available information, we conclude that fibrous glass materials are carcinogenic, and in view of the NTP and IARC definitions should be listed in the ARC. Our review then examines the carcinogenic potency of glass fibers to humans in comparison with asbestos fibers and concludes that on a fiber-per-fiber basis, glass fibers may be as potent or even more potent than asbestos. The implications of these findings are then presented for regulatory purposes in the occupational setting.
一些人认为，玻璃纤维（玻璃棉）不应被视为可能的人类致癌物，因此不应列入由美国国家毒理学计划（NTP）编写并由美国国会授权发布的《第七份致癌物年度报告》（ARC）中。在审视这个问题时，我们回顾了来自实验室实验（动物研究）和流行病学研究（人类数据）的数据，并根据国际癌症研究机构（IARC）制定、NTP以略有修改的形式采用的将物质分类为人类致癌物或可能的人类致癌物的标准来评估结果。通过对现有信息的全面审查，我们得出结论，玻璃纤维材料具有致癌性，鉴于NTP和IARC的定义，应将其列入ARC。我们的审查随后将玻璃纤维对人类的致癌效力与石棉纤维进行了比较，并得出结论，基于每根纤维而言，玻璃纤维的致癌效力可能与石棉相当，甚至更强。然后，我们针对职业环境中的监管目的阐述了这些发现的影响。
