Baan Robert A, Grosse Yann
Unit of Carcinogen Identification and Evaluation, WHO-International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon cedex 08, France.
Mutat Res. 2004 Sep 3;553(1-2):43-58. doi: 10.1016/j.mrfmmm.2004.06.019.
Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations of the carcinogenic hazards of exposure to man-made mineral fibres (MMMF, Monograph volume 43, [1]) and man-made vitreous fibres (MMVF, Monograph volume 81, [2]) are summarised, and the differences explained. In particular, the considerations of the respective IARC Monographs Working Groups (1987, 2001) in reaching their conclusions are discussed in some detail.
人造玻璃(玻璃状)纤维是一种非晶态的纤维状无机物质(硅酸盐),主要由岩石、矿渣、玻璃或其他加工矿物制成。这些材料,也称为人造矿物纤维,包括玻璃纤维(用于玻璃棉和连续玻璃丝)、岩棉或石棉、矿渣棉和耐火陶瓷纤维。它们广泛用于隔热和隔音,在较小程度上用于其他目的。这些产品对人类健康有潜在危害,因为它们在生产、使用和拆除过程中会释放可吸入的空气传播纤维。人造矿物纤维和人造玻璃纤维分别在1987年和2001年成为国际癌症研究机构专论工作组审查的对象,审查结果是对接触这些材料对人类致癌风险的评估。这些审查和评估已作为国际癌症研究机构专论系列的第43卷和第81卷出版[《国际癌症研究机构关于评估对人类致癌风险的专论》,第43卷,人造矿物纤维和氡(1988年);《国际癌症研究机构关于评估对人类致癌风险的专论》,第81卷,人造玻璃纤维(2002年)]。2001年进行重新评估是因为在玻璃纤维、连续玻璃丝和岩棉对人类致癌性的现有流行病学信息质量方面有了实质性改进。新的评估解决了早期队列研究的局限性,特别是在缺乏对吸烟和其他职业接触来源等伴随风险因素的调整方面。此外,通过区分隔热玻璃棉和特殊用途玻璃纤维,对玻璃纤维对实验动物致癌性证据的评估得到了完善。因此,1987年和2001年的评估结果在几个方面有所不同。本文总结了对接触人造矿物纤维(MMMF,专论第43卷,[1])和人造玻璃纤维(MMVF,专论第81卷,[2])致癌风险的审查和评估,并解释了差异。特别是,详细讨论了国际癌症研究机构专论工作组(1987年、2001年)得出结论时的考虑因素。
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