Nanko S, Fukuda R, Hattori M, Sasaki T, Dai X Y, Yamaguchi K, Kazamatsuri H
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Am J Med Genet. 1994 Sep 15;54(3):264-7. doi: 10.1002/ajmg.1320540315.
The dopamine hypothesis of schizophrenia proposed that dopaminergic pathways are involved in the etiology of the disease. In particular, interest among psychiatrists has focused on the D2 receptor because of its affinity to antipsychotic drugs. Recently a new dopamine receptor gene has been cloned, and named the dopamine D3 receptor. The D3 receptor is a potential site for antipsychotic drug action and may be involved in the pathophysiology of schizophrenia. We have carried out a linkage study between the susceptibility gene for schizophrenia and polymorphism of the dopamine D3 receptor gene in two Japanese pedigrees. The LOD scores were negative for all genetic models and for all affective status at a recombination fraction theta = 0. Linkage of DRD3 has been excluded for the model 1 (dominant model) and the model 3 (recessive model). The LOD score was -3.43 at theta = 0 for model 1 (dominant model) and broad definition of affected status. These results were consistent with previous studies.
精神分裂症的多巴胺假说提出，多巴胺能通路参与了该疾病的病因。特别是，由于D2受体与抗精神病药物的亲和力，精神科医生的兴趣集中在该受体上。最近，一个新的多巴胺受体基因被克隆出来，并被命名为多巴胺D3受体。D3受体是抗精神病药物作用的一个潜在位点，可能参与了精神分裂症的病理生理学过程。我们在两个日本家系中对精神分裂症易感基因与多巴胺D3受体基因多态性进行了连锁研究。在重组率θ = 0时，所有遗传模型和所有情感状态的对数优势比（LOD）分数均为阴性。对于模型1（显性模型）和模型3（隐性模型），已排除DRD3的连锁关系。对于模型1（显性模型）和宽泛的患病状态定义，在θ = 0时LOD分数为-3.43。这些结果与先前的研究一致。
