安素肠内营养对氧氟沙星和环丙沙星口服生物利用度的影响。
Effect of enteral feeding with ensure on oral bioavailabilities of ofloxacin and ciprofloxacin.
作者信息
Mueller B A, Brierton D G, Abel S R, Bowman L
机构信息
Department of Pharmacy Practice, Purdue University, West Lafayette, Indiana 47907.
出版信息
Antimicrob Agents Chemother. 1994 Sep;38(9):2101-5. doi: 10.1128/AAC.38.9.2101.
Abstract
The relative oral bioavailabilities of ciprofloxacin and ofloxacin when they were coadministered with water or an enteral feeding product (Ensure) were assessed in 13 healthy volunteers. The area under the concentration time curve from time zero to infinity and the maximum concentration of drug in serum for both drugs were reduced by Ensure in comparison with those by water (P < 0.01). However, Ensure reduced the percent relative bioavailability of ciprofloxacin (72% +/- 14%; range, 52 to 96%) significantly more than ofloxacin (90% +/- 8.3%; range, 74 to 105%) (P < 0.005). Coadministration of Ensure significantly diminished ciprofloxacin and ofloxacin absorption, but ciprofloxacin absorption was reduced significantly more than ofloxacin absorption.
摘要
在13名健康志愿者中评估了环丙沙星和氧氟沙星与水或肠内营养产品（安素）共同给药时的相对口服生物利用度。与水相比，安素使两种药物从零时间到无穷大的浓度-时间曲线下面积以及血清中药物的最大浓度均降低（P<0.01）。然而，安素使环丙沙星的相对生物利用度百分比（72%±14%；范围为52%至96%）降低的幅度明显大于氧氟沙星（90%±8.3%；范围为74%至105%）（P<0.005）。安素共同给药显著减少了环丙沙星和氧氟沙星的吸收，但环丙沙星吸收的减少幅度明显大于氧氟沙星。
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