碳酸钙长期给药对口服环丙沙星生物利用度的影响。
The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin.
作者信息
Sahai J, Healy D P, Stotka J, Polk R E
机构信息
Department of Medicine, Ottawa General Hospital, Ontario, Canada.
出版信息
Br J Clin Pharmacol. 1993 Mar;35(3):302-4.
Abstract
Six healthy male volunteers participated in a two-period, two-treatment study to determine the effect of chronic calcium carbonate administration on ciprofloxacin bioavailability. There was a mean reduction of 40% in Cmax and 43% in AUC when calcium carbonate was administered with ciprofloxacin, compared with ciprofloxacin alone (P < 0.05). There were no changes in either half-life or tmax. It is therefore recommended that patients being treated with ciprofloxacin for serious infections refrain from ingesting calcium supplements. If this is not possible, administration of ciprofloxacin 2 h before ingestion of the supplement is suggested.
摘要
六名健康男性志愿者参与了一项为期两阶段、两种治疗方法的研究，以确定长期服用碳酸钙对环丙沙星生物利用度的影响。与单独服用环丙沙星相比，碳酸钙与环丙沙星联用时，Cmax平均降低了40%，AUC平均降低了43%（P < 0.05）。半衰期和tmax均无变化。因此，建议正在使用环丙沙星治疗严重感染的患者避免摄入钙补充剂。如果无法做到这一点，建议在摄入补充剂前2小时服用环丙沙星。
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