Brivet F G, Naveau S H, Lemaigre G F, Dormont J
Department of Intrernal Medicine, Hôpital Antoine Béclère, Clamart, France.
Baillieres Clin Endocrinol Metab. 1994 Oct;8(4):859-77. doi: 10.1016/s0950-351x(05)80306-4.
The pancreas is frequently involved during HIV infection, especially by disseminated infections or neoplasms. These lesions are generally asymptomatic and are discovered at autopsy. However, hypoglycaemia secondary to massive pancreatic infiltration by a tumour or tuberculous necrosis may occur. The most important cause of pancreatic dysfunction in HIV-infected patients is a drug toxic effect (intravenous pentamidine, didanosine, zalcitabine). Hypoglycaemia, which may or may not be followed by diabetes, can develop during intravenous pentamidine therapy. In cases with increased serum amylase and/or lipase levels, potentially toxic drugs must be promptly discontinued to avoid major pancreatic involvement.
胰腺在HIV感染期间经常受累，尤其是通过播散性感染或肿瘤。这些病变通常无症状，在尸检时发现。然而，肿瘤大量浸润胰腺或结核性坏死继发的低血糖可能会发生。HIV感染患者胰腺功能障碍的最重要原因是药物毒性作用（静脉注射喷他脒、去羟肌苷、扎西他滨）。静脉注射喷他脒治疗期间可能会发生低血糖，低血糖可能会或不会继发糖尿病。在血清淀粉酶和/或脂肪酶水平升高的情况下，必须立即停用潜在有毒药物，以避免胰腺严重受累。
