Terness P, Kirschfink M, Navolan D, Dufter C, Kohl I, Opelz G, Roelcke D
Institute of Immunology, University of Heidelberg, Germany.
Blood. 1995 Jan 15;85(2):548-51.
Previous experiments showed that the physiologic IgG anti-F(ab')2 antibody suppresses the response of human autoreactive B cells. In the present study, we analyzed the IgG anti-F(ab')2 antibody in 293 patients with cold agglutination (CA). Their average IgG anti-F(ab')2 titer was not much different (211 +/- 8.3) from that of 279 healthy persons (195 +/- 6.7). However, CA patients with high anti-F(ab')2 titers had low CA autoantibody titers and vice versa (P = .0028; rho = -0.175). The stratification of patients according to the auto-antibody's specificity (anti-I, anti-i, anti-Pr) showed an inverse correlation between anti-F(ab')2 and CA in the anti-I group (P = .0057; rho = -0.180). Interestingly, the association was present only in patients whose disease was caused by noninfectious agents (P < .0001; rho = -0.423). The inverse correlation argues for an important role of the IgG anti-F(ab')2 in the regulation of autoantibody production in CA patients.
先前的实验表明，生理性IgG抗F(ab')2抗体可抑制人类自身反应性B细胞的反应。在本研究中，我们分析了293例冷凝集（CA）患者体内的IgG抗F(ab')2抗体。他们的平均IgG抗F(ab')2滴度与279名健康人的平均滴度（195±6.7）相比，差异不大（211±8.3）。然而，抗F(ab')2滴度高的CA患者，其CA自身抗体滴度较低，反之亦然（P = 0.0028；rho = -0.175）。根据自身抗体特异性（抗-I、抗-i、抗-Pr）对患者进行分层分析发现，在抗-I组中，抗F(ab')2与CA之间呈负相关（P = 0.0057；rho = -0.180）。有趣的是，这种关联仅存在于由非感染因素引起疾病的患者中（P < 0.0001；rho = -0.423）。这种负相关表明IgG抗F(ab')2在CA患者自身抗体产生的调节中起重要作用。
