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类风湿关节炎和系统性红斑狼疮中的IgM和IgG抗F(ab')2抗体

IgM and IgG anti-F(ab')2 antibodies in rheumatoid arthritis and systemic lupus erythematosus.

作者信息

Heimer R, Wolfe L D, Abruzzo J L

出版信息

Arthritis Rheum. 1982 Nov;25(11):1298-1306. doi: 10.1002/art.1780251105.

DOI:10.1002/art.1780251105
PMID:6982718
Abstract

Radioimmunoassays for anti-F(ab')2 antibodies, which feature the use of goat anti-human Fc antibody for correcting potentiation of IgM anti-F(ab')2 antibody titers by endogenous IgM anti-Fc antibodies (rheumatoid factors), are described. Individuals with classic rheumatoid arthritis had significantly more IgM anti-F(ab')2 antibody (P less than 0.001) and IgG anti-F(ab')2 antibody (P = 0.05) than did individuals with systemic lupus erythematosus or normal volunteers. There is some similarity in patterns of isotype distribution of anti-F(ab')2 antibodies and rheumatoid factors.

摘要

本文描述了抗F(ab')2抗体的放射免疫测定法，该方法的特点是使用山羊抗人Fc抗体来校正内源性IgM抗Fc抗体（类风湿因子）对IgM抗F(ab')2抗体效价的增强作用。典型类风湿关节炎患者的IgM抗F(ab')2抗体（P<0.001）和IgG抗F(ab')2抗体（P = 0.05）明显多于系统性红斑狼疮患者或正常志愿者。抗F(ab')2抗体和类风湿因子的同种型分布模式存在一些相似性。

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