Copson E R, Ellis B A, Westwood N B, Majumdar G
Division of Haematology, United Medical School, Guy's Hospital, London, UK.
Leuk Lymphoma. 1994 Aug;14(5-6):471-3. doi: 10.3109/10428199409049706.
Patients with B-cell chronic lymphocytic leukaemia (BCLL) have low levels of serum IgG. In order to determine if this is a pan IgG deficiency or a selective suppression of one or more IgG subclasses, levels of IgG 1, 2, 3 and 4 in nine BCLL patients were determined and compared to those of nine age and sex matched controls. No significant differences were found in the levels of IgG1 and IgG2, but the patients were found to have significantly lower levels of IgG3 (p < 0.05) and IgG4 (p < 0.05). Selective deficiencies of these isotypes may explain the particular pattern of infection seen in BCLL patients.
B细胞慢性淋巴细胞白血病（BCLL）患者的血清IgG水平较低。为了确定这是全IgG缺乏还是一种或多种IgG亚类的选择性抑制，测定了9例BCLL患者的IgG 1、2、3和4水平，并与9例年龄和性别匹配的对照者进行了比较。IgG1和IgG2水平未发现显著差异，但发现患者的IgG3（p < 0.05）和IgG4（p < 0.05）水平显著较低。这些同种型的选择性缺乏可能解释了BCLL患者中所见的特定感染模式。
