Barbaccia M L, Roscetti G, Trabucchi M, Cuccheddu T, Concas A, Biggio G
Dipartimento di Medicina Sperimentale, Università di Roma Tor Vergata, Italy.
Eur J Pharmacol. 1994 Aug 22;261(3):317-20. doi: 10.1016/0014-2999(94)90123-6.
In rats habituated to the manipulation that precedes killing (handling-habituated) the cerebral cortical concentrations of pregnenolone and progesterone were significantly lower (-57% and -69%, respectively) than in naive animals. An acute stress, induced by CO2 inhalation, elicited a marked increase in the concentrations of pregnenolone, progesterone and deoxycorticosterone in the brain cortex and hippocampus of handling-habituated rats. An accepted stress, such as foot shock, also enhanced the brain cortical levels of pregnenolone, progesterone and deoxycorticosterone in handling-habituated rats. These data show that the rat brain cortical and hippocampal steroid content is related to the 'emotional state' of the animal.
在习惯于处死前操作（习惯处理）的大鼠中，孕烯醇酮和孕酮的大脑皮质浓度显著低于未处理的动物（分别降低了57%和69%）。由吸入二氧化碳诱导的急性应激，使习惯处理的大鼠大脑皮质和海马体中孕烯醇酮、孕酮和脱氧皮质酮的浓度显著增加。一种公认的应激，如足部电击，也会提高习惯处理的大鼠大脑皮质中孕烯醇酮、孕酮和脱氧皮质酮的水平。这些数据表明，大鼠大脑皮质和海马体中的类固醇含量与动物的“情绪状态”有关。
