Rudd J A, Jordan C C, Naylor R J
School of Pharmacy, University of Bradford, UK.
Eur J Pharmacol. 1994 Sep 1;262(1-2):R1-2. doi: 10.1016/0014-2999(94)90048-5.
The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 40 h period respectively. Cisplatin 10 mg/kg induced retching and vomiting which rapidly declined after the first 8 h. Cisplatin 5 mg/kg induced a less intense emetic response which declined after 16 h but reappeared at approximately 32 h to reveal a 'delayed' retching and vomiting response. The use of cisplatin 5 mg/kg may offer a regimen to model cytotoxic acute and delayed emesis.
分别在雪貂身上研究了腹腔注射5毫克/千克和10毫克/千克顺铂在72小时和40小时内的催吐作用特征。10毫克/千克的顺铂会引发干呕和呕吐，在最初8小时后迅速减少。5毫克/千克的顺铂引发的催吐反应较弱，在16小时后减少，但在大约32小时时再次出现，呈现出“延迟性”干呕和呕吐反应。使用5毫克/千克的顺铂可能提供一种用于模拟细胞毒性急性和延迟性呕吐的方案。
