Sakagami M, Niki H
Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
Exp Brain Res. 1994;100(1):165-9. doi: 10.1007/BF00227290.
We examined single-unit activity in the inferior prefrontal cortex during a visual go/no-go discrimination task under maintained visual fixation. The monkeys had to base their response on either the color, shape, or position of a discriminative cue, and the relevant task condition was indicated by the color of the fixation spot. We analyzed the spatial selectivity of 128 go/no-go neurons showing a marked differential cue-period activity that depended on whether the stimulus signaled a go or no-go response. Most of these neurons (n = 106, 83%) showed asymmetry between their responses to stimuli in the contralateral and ipsilateral visual fields. Seventy-seven of these neurons had a contralateral preferential field, and 29 had an ipsilateral preferential field. These results show that in many inferior prefrontal neurons a degree of differentiation in their responses to go and no-go stimuli depends on the cue positions, and that the coding of behavioral meaning is carried out mainly in the contralateral hemisphere.
我们在视觉固定保持状态下的视觉“去/不去”辨别任务中，检查了前额叶下部皮质的单神经元活动。猴子必须根据辨别线索的颜色、形状或位置做出反应，而相关任务条件由固定点的颜色指示。我们分析了128个“去/不去”神经元的空间选择性，这些神经元在提示期表现出明显的差异活动，这取决于刺激信号是“去”反应还是“不去”反应。这些神经元中的大多数（n = 106，83%）对同侧和对侧视野刺激的反应表现出不对称性。其中77个神经元有对侧优先视野，29个有同侧优先视野。这些结果表明，在许多前额叶下部神经元中，它们对“去”和“不去”刺激反应的分化程度取决于线索位置，并且行为意义的编码主要在对侧半球进行。
