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主动脉移植物感染保守治疗的八年经验

An eight year experience of conservative management for aortic graft sepsis.

作者信息

Gordon A, Conlon C, Collin J, Peto T, Gray D, Hands L, Morris P

机构信息

Nuffield Department of Surgery, University of Oxford, U.K.

出版信息

Eur J Vasc Surg. 1994 Sep;8(5):611-6. doi: 10.1016/s0950-821x(05)80600-0.

Abstract

This paper describes the results of conservative management of 15 patients with aortic graft infection. The median time to presentation was 4 months. Six of eight grafts that were sent for culture grew organisms, of which the commonest were streptococci and coagulase negative staphylococci. Four patients did not receive intensive antibiotic treatment and all died of sepsis. Eleven patients received intensive intravenous and oral antibiotic therapy and appropriate surgical management; two of these died, one of a stroke and the other of an unknown cause. Two of the nine surviving patients had no surgery and the remainder had procedures to drain pus and unblock occluded grafts, including minimal graft excision in four patients, although two of these subsequently required total graft excision. The follow-up period for six of these nine patients is more than 4 years. For most patients with aortic graft infection aggressive antibiotic treatment supplemented by minimalist surgery is preferable to primary radical surgery.

摘要

本文描述了15例主动脉移植物感染患者的保守治疗结果。就诊的中位时间为4个月。送去培养的8个移植物中有6个培养出微生物,其中最常见的是链球菌和凝固酶阴性葡萄球菌。4例患者未接受强化抗生素治疗,均死于败血症。11例患者接受了强化静脉和口服抗生素治疗以及适当的手术处理;其中2例死亡,1例死于中风,另1例死因不明。9例存活患者中有2例未接受手术,其余患者进行了引流脓液和疏通闭塞移植物的操作,包括4例患者进行了最小限度的移植物切除,不过其中2例随后需要进行全移植物切除。这9例患者中有6例的随访期超过4年。对于大多数主动脉移植物感染患者,积极的抗生素治疗辅以微创外科手术优于初次根治性手术。

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