Jarvik G P, Austin M A, Fabsitz R R, Auwerx J, Reed T, Christian J C, Deeb S
Department of Medicine, School of Public Health and Community Medicine, University of Washington, Seattle.
Genet Epidemiol. 1994;11(4):375-84. doi: 10.1002/gepi.1370110407.
This study addressed the possible influence of apolipoprotein E (apo E) genotype on age-related changes in total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) levels in older males. Apo E is a component of LDL, is a ligand for the LDL receptor, and apo E genotype has been consistently associated with variation in mean levels of TC and LDL-C, and also appears to influence TG levels. Using male twins followed longitudinally between mean ages of 48 and 63 years, the change in TC, LDL-C, and TG over time for individuals with the epsilon 3 epsilon 3 and the epsilon 3 epsilon 4 genotypes was contrasted. At exam 1 mean TC and LDL-C levels were lower in the epsilon 3 epsilon 3 group than in the epsilon 3 epsilon 4 group, but at exam 3 mean TC and LDL-C levels were significantly higher in the epsilon 3 epsilon 3 group than in the epsilon 3 epsilon 4 group. The rate of change in TC and LDL-C with age differed significantly between epsilon 3 epsilon 3 and epsilon 3 epsilon 4 groups. Results for TG were not statistically significantly. These findings suggest that the apo E genotype effects on risk of coronary artery disease may be age-dependent. This study demonstrates the value of longitudinal studies in refining models for genetic risk factors for disease.
本研究探讨了载脂蛋白E（apo E）基因型对老年男性总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）水平随年龄变化的可能影响。Apo E是低密度脂蛋白的一个组成部分，是低密度脂蛋白受体的配体，并且apo E基因型一直与TC和LDL-C平均水平的变化相关，而且似乎也会影响TG水平。利用48至63岁之间接受纵向随访的男性双胞胎，对比了ε3ε3和ε3ε4基因型个体的TC、LDL-C和TG随时间的变化情况。在第一次检查时，ε3ε3组的平均TC和LDL-C水平低于ε3ε4组，但在第三次检查时，ε3ε3组的平均TC和LDL-C水平显著高于ε3ε4组。ε3ε3和ε3ε4组之间，TC和LDL-C随年龄的变化率存在显著差异。TG的结果无统计学显著差异。这些发现表明，apo E基因型对冠状动脉疾病风险的影响可能与年龄有关。本研究证明了纵向研究在完善疾病遗传风险因素模型方面的价值。
