Kangasniemi I M, Vähätalo K, Happonen R P, Yli-Urpo A, de Groot K
Biomaterials Project, University of Turku, Finland.
J Biomed Mater Res. 1994 Sep;28(9):993-1002. doi: 10.1002/jbm.820280904.
Four Ca,P particle containing surface reactive glass composites and two glasses (in the SiO2-CaO-P2O5-Na2O-Al2O3-B2O3 system) were implanted in the diaphyseal area of goat femora up to 24 weeks. Scanning electron microscopic, energy dispersive x-ray, and histological analysis were performed to evaluate the material-tissue interactions. A new type of integration mechanism was observed. Instead of the bone growing to the material surface, a gel-like silica formation appeared between the cortex bone and the material surface. In time the gel-like formation was replaced by a Ca,P layer. The results provided indirect evidence that pure silica gel formed in the tissues could also achieve an apatite layer formation and bone bonding on its surface.
将四种含钙磷颗粒的表面活性玻璃复合材料和两种玻璃（在SiO₂-CaO-P₂O₅-Na₂O-Al₂O₃-B₂O₃体系中）植入山羊股骨骨干区域长达24周。进行扫描电子显微镜、能量色散X射线和组织学分析以评估材料与组织的相互作用。观察到一种新型的整合机制。不是骨长到材料表面，而是在皮质骨和材料表面之间出现了凝胶状二氧化硅形成物。随着时间的推移，凝胶状形成物被钙磷层取代。结果提供了间接证据，表明在组织中形成的纯硅胶也能在其表面形成磷灰石层并实现骨结合。
