甲硫米特治疗十二指肠溃疡。一项多中心试验。
Treatment of duodenal ulcer by metiamide. A multicentre trial.
出版信息
Lancet. 1975 Oct 25;2(7939):779-81.
PMID:78150
Abstract
In a multicentre double-blind trial 68 patients with endoscopically confirmed duodenal ulceration received metiamide (36 patients) or placebo (32 patients) for four weeks. Healing of duodenal ulcers was significantly increased in patients receiving metiamide (67%) compared with those on placebo (25%). There was also an assoicated significant decrease in daytime pain and antacid consumption in those on metiamide.
摘要
在一项多中心双盲试验中，68例经内镜确诊为十二指肠溃疡的患者接受了甲硫米特（36例患者）或安慰剂（32例患者）治疗，为期四周。与接受安慰剂的患者（25%）相比，接受甲硫米特治疗的患者十二指肠溃疡愈合率显著提高（67%）。接受甲硫米特治疗的患者白天疼痛和抗酸剂消耗量也显著降低。
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