口服甲硫米特缓解十二指肠溃疡症状。
Relief of duodenal ulcer sysmptons by oral metiamide.
作者信息
Pounder R E, Williams J G, Milton-Thompson G J, Misiewicz J J
出版信息
Br Med J. 1975 May 10;2(5966):307-9. doi: 10.1136/bmj.2.5966.307.
Abstract
Thirty patients with symptoms of duodenal ulceration were treated for five to eight weeks in a double-blind trial with either metiamide 1 g daily by mouth or a placebo. In the 15 patients receiving metiamide there were significant reductions in nocturnal pain and antacid consumption. Daytime pain was diminished. The results suggest that histamine H2-receptor antagonists are likely to be useful in the medical management of the symptoms of duodenal ulceration.
摘要
在一项双盲试验中，30名有十二指肠溃疡症状的患者接受了为期五至八周的治疗，一组每天口服1克甲硫米特，另一组服用安慰剂。在接受甲硫米特治疗的15名患者中，夜间疼痛和抗酸剂消耗量显著减少。白天疼痛也有所减轻。结果表明，组胺H2受体拮抗剂可能对十二指肠溃疡症状的药物治疗有用。
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本文引用的文献
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Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in man.组胺H2受体拮抗剂甲硫米特对人体胃对组胺、五肽胃泌素、胰岛素和蛋白胨餐反应的影响。
Am J Dig Dis. 1974 Jul;19(7):609-16. doi: 10.1007/BF01073015.
2
Gastric response to metiamide.胃对甲硫米特的反应。
Br Med J. 1974 May 11;2(5914):304-6. doi: 10.1136/bmj.2.5914.304.
3
Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.组胺H2受体阻断对人体迷走神经诱导的胃酸分泌的影响。
Br Med J. 1974 Aug 31;3(5930):554-6. doi: 10.1136/bmj.3.5930.554.
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Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer.甲硫米特，一种H2受体阻滞剂，作为十二指肠溃疡患者基础胃酸分泌和进餐刺激胃酸分泌的抑制剂。
N Engl J Med. 1974 Aug 22;291(8):373-6. doi: 10.1056/NEJM197408222910801.
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Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide.单次口服甲硫米特对十二指肠溃疡夜间酸分泌的抑制作用。
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