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[术后预防血栓栓塞中不同制剂乙酰水杨酸的胃耐受性(作者译)]

[Gastric tolerance of different preparations of acetylsalicylic acid in postoperative prevention of thrombo-embolism (author's transl)].

作者信息

Knote G, Vielsäcker H, Mappes G

出版信息

Med Klin. 1976 Jul 23;71(30):1235-8.

PMID:781501
Abstract

The necessity for thrombosis-prophylaxis is indisputable. The evaluation of our patients over a period of 2 years revealed results compatible with other authors. Due to its thrombocyte desaggregating action, acetyl-salicylic acid was found to have a definite effect on the thrombophilia by inhibiting the thrombocyte adhesiveness in a beginning thrombosis. It was shown that acetylsalicylic acid in combination with glycocoll is apparently superior to microencapsulated acetylic acid in terms of gastric tolerance. In a small number of patients the therapeutic efficiency was investigated and according to the platelets agglutination test, verified. Further investigations are planned in a major series of patients where acetylsalicylic acid with glycocoll was administered in respect to the treatment of rheumatic fever.

摘要

血栓预防的必要性是无可争议的。我们对患者进行了为期两年的评估,结果与其他作者的研究结果相符。由于乙酰水杨酸具有血小板解聚作用,通过抑制血栓形成初期的血小板黏附性,发现其对血栓形成倾向有明确作用。结果表明,就胃耐受性而言,乙酰水杨酸与甘氨酸组合明显优于微囊化乙酰水杨酸。在少数患者中对治疗效果进行了研究,并根据血小板凝集试验进行了验证。计划对大量患者进行进一步研究,这些患者将接受乙酰水杨酸与甘氨酸组合治疗风湿热。

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