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本文引用的文献

1
Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box.人类巨细胞病毒IE86蛋白与顺式抑制信号的直接相互作用并不妨碍TBP与TATA盒结合。
J Virol. 1993 Sep;67(9):5595-604. doi: 10.1128/JVI.67.9.5595-5604.1993.
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Epstein-Barr virus gene expression in oral hairy leukoplakia.口腔毛状白斑中的爱泼斯坦-巴尔病毒基因表达
Virology. 1993 Aug;195(2):463-74. doi: 10.1006/viro.1993.1397.
3
Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions.丙型肝炎病毒的非结构蛋白3编码一种丝氨酸型蛋白酶，该酶是NS3/4和NS4/5连接处切割所必需的。
J Virol. 1993 Jul;67(7):3835-44. doi: 10.1128/JVI.67.7.3835-3844.1993.
4
Characterization of the protease and other products of amino-terminus-proximal cleavage of the herpes simplex virus 1 UL26 protein.单纯疱疹病毒1型UL26蛋白氨基末端近端切割的蛋白酶及其他产物的特性分析
J Virol. 1993 Mar;67(3):1300-9. doi: 10.1128/JVI.67.3.1300-1309.1993.
5
Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites.人巨细胞病毒UL80编码蛋白酶的表达与分析：自蛋白水解位点的鉴定
J Virol. 1993 Jan;67(1):497-506. doi: 10.1128/JVI.67.1.497-506.1993.
6
Investigation of the specificity of the herpes simplex virus type 1 protease by point mutagenesis of the autoproteolysis sites.通过对自切割位点进行点突变研究单纯疱疹病毒1型蛋白酶的特异性。
J Virol. 1994 Jan;68(1):526-9. doi: 10.1128/JVI.68.1.526-529.1994.
7
Human cytomegalovirus IE86 protein interacts with promoter-bound TATA-binding protein via a specific region distinct from the autorepression domain.人巨细胞病毒IE86蛋白通过一个不同于自身抑制结构域的特定区域与启动子结合的TATA结合蛋白相互作用。
J Virol. 1993 Dec;67(12):7539-46. doi: 10.1128/JVI.67.12.7539-7546.1993.
8
Herpesvirus proteinase: site-directed mutagenesis used to study maturational, release, and inactivation cleavage sites of precursor and to identify a possible catalytic site serine and histidine.疱疹病毒蛋白酶：利用定点诱变研究前体的成熟、释放和失活切割位点，并鉴定可能的催化位点丝氨酸和组氨酸。
J Virol. 1993 Dec;67(12):7360-72. doi: 10.1128/JVI.67.12.7360-7372.1993.
9
The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.单纯疱疹病毒1型的蛋白酶对于功能性衣壳的形成和病毒生长至关重要。
J Virol. 1994 Jun;68(6):3702-12. doi: 10.1128/JVI.68.6.3702-3712.1994.
10
Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins.在感染了表达单纯疱疹病毒（HSV）衣壳蛋白的重组杆状病毒的昆虫细胞中组装HSV中间衣壳。
J Virol. 1994 Apr;68(4):2442-57. doi: 10.1128/JVI.68.4.2442-2457.1994.

爱泼斯坦-巴尔病毒蛋白酶的特性及其与人巨细胞病毒蛋白酶的比较。

Characterization of the Epstein-Barr virus proteinase and comparison with the human cytomegalovirus proteinase.

作者信息

Donaghy G, Jupp R

机构信息

Department of Biology, Roche Research Centre, Welwyn Garden City, Hertfordshire, United Kingdom.

出版信息

J Virol. 1995 Feb;69(2):1265-70. doi: 10.1128/JVI.69.2.1265-1270.1995.

DOI:10.1128/JVI.69.2.1265-1270.1995
PMID:7815503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188701/
Abstract

The BVRF2 gene of Epstein-Barr virus (EBV) shows homology to the UL26 and UL80 genes of herpes simplex virus type 1 (HSV-1) and cytomegalovirus (CMV), respectively. These genes are believed to provide a scaffold protein for the assembly of capsids leading to the formation of infectious viral particles. We have cloned the BVRF2 gene from the B95.8 strain of EBV and shown that the BVRF2 gene product is a polyprotein capable of autoproteolytic cleavage. Two Ala-Ser-containing recognition sequences were identified in the BVRF2 polyprotein at amino acid positions 568/569 and 570/571 where this cleavage was expected to occur. Here, we show that EBV proteinase is capable of cleaving at the first Ala-Ser bond but not the second. Comparison of the processing of the EBV and human CMV assembly domains in vitro by either EBV or human CMV proteinase revealed that, while both proteinases could cleave their native assembly domain, only EBV proteinase was able to cleave the assembly domain of the other virus.

摘要

爱泼斯坦-巴尔病毒（EBV）的BVRF2基因分别与单纯疱疹病毒1型（HSV-1）的UL26基因和巨细胞病毒（CMV）的UL80基因具有同源性。据信这些基因可为衣壳组装提供一种支架蛋白，从而导致感染性病毒颗粒的形成。我们从EBV的B95.8菌株中克隆了BVRF2基因，并表明BVRF2基因产物是一种能够进行自蛋白水解切割的多蛋白。在BVRF2多蛋白中，预期切割会发生的氨基酸位置568/569和570/571处鉴定出了两个含丙氨酸-丝氨酸的识别序列。在此，我们表明EBV蛋白酶能够在第一个丙氨酸-丝氨酸键处切割，但不能在第二个键处切割。通过EBV或人CMV蛋白酶对EBV和人CMV组装结构域在体外的加工过程进行比较，结果显示，虽然两种蛋白酶都能切割其天然组装结构域，但只有EBV蛋白酶能够切割另一种病毒的组装结构域。