Russell D H, Durie B G, Salmon S E
Lancet. 1975 Oct 25;2(7939):797-9. doi: 10.1016/s0140-6736(75)80009-2.
Polyamines appear to have clinical utility for monitoring cancer therapy. Investigations on the patterns of urinary excretion of polyamines in patients receiving cancer chemotherapy and studies of the tritiated-thymidine labelling index of tumour cells in a subgroup of these patients form the basis for a hypothesis that spermidine can serve as a marker of tumour-cell kill, whereas putrescine appears to reflect the proliferative behaviour or "growth fraction" of the tumour. Although tests of this hypothesis are necessary to establish the predictive value of polyamines for monitoring cancer therapy, it is clear that polyamines may provide important new information on tumour cytokinetic parameters.
多胺似乎在监测癌症治疗方面具有临床应用价值。对接受癌症化疗患者的多胺尿排泄模式的研究以及对这些患者亚组中肿瘤细胞的氚标记胸腺嘧啶核苷标记指数的研究，构成了一个假说的基础，即亚精胺可作为肿瘤细胞杀伤的标志物，而腐胺似乎反映了肿瘤的增殖行为或“生长分数”。尽管需要对这一假说进行检验以确定多胺在监测癌症治疗方面的预测价值，但很明显，多胺可能会提供有关肿瘤细胞动力学参数的重要新信息。
