使用培养的哺乳动物细胞对顺二氯二氨合铂（II）和外源性多胺进行的研究。
Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.
作者信息
Roizin-Towle L
出版信息
Br J Cancer. 1981 Mar;43(3):378-83. doi: 10.1038/bjc.1981.58.
Abstract
Polyamines, such as putrescine and spermine, are naturally occurring substances intimately associated with normal and neoplastic growth. High levels are found in cancer patients and are associated with tumour growth. Experiments with V79 hamster cells cultured in vitro have demonstrated that the presence of putrescine and spermine can significantly reduce the cytotoxicity of the commonly used chemotherapy agent cis-DDP. These data may have clinical implications.
摘要
多胺，如腐胺和精胺，是与正常生长和肿瘤生长密切相关的天然存在的物质。在癌症患者体内发现其水平较高，且与肿瘤生长有关。对体外培养的V79仓鼠细胞进行的实验表明，腐胺和精胺的存在可显著降低常用化疗药物顺铂的细胞毒性。这些数据可能具有临床意义。
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Studies with cis-diamminedichloro-platinum II and exogenous polyamines using mammalian cells in culture.使用培养的哺乳动物细胞对顺二氯二氨合铂（II）和外源性多胺进行的研究。
Br J Cancer. 1981 Mar;43(3):378-83. doi: 10.1038/bjc.1981.58.
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本文引用的文献
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Modulation of membrane protein lateral mobility by polyphosphates and polyamines.多磷酸盐和多胺对膜蛋白侧向流动性的调节作用。
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Regulation of meningioma cell growth in vitro by polyamines.多胺对体外脑膜瘤细胞生长的调控
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Polyamines as markers of response and disease activity in cancer chemotherapy.多胺作为癌症化疗中反应和疾病活动的标志物。
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A review of platinum complex biochemistry suggests a rationale for combined platinum-radiotherapy.对铂配合物生物化学的综述为铂-放疗联合治疗提供了理论依据。
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