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从普通感冒到癌症:进化与现代生活方式似乎是如何导致这些情况发生的。

From the common cold to cancer: how evolution and the modern lifestyle appear to have contributed to such eventualities.

作者信息

Leeming R A

出版信息

Med Hypotheses. 1994 Sep;43(3):145-50. doi: 10.1016/0306-9877(94)90140-6.

DOI:10.1016/0306-9877(94)90140-6
PMID:7815966
Abstract

This hypothesis suggests that psychosocial stress is the pivotal determinator of many modern day disorders in consequence to consuming today's nutritional intakes of ascorbic acid and sodium. For it seems, as a result of our tropical African evolution, present day intakes of these essential nutrients are incompatible with the maintenance of bodily homeostasis when the body is subjected to any form of stress. In addition, the climatic conditions under which most of us live are seemingly ill-suited to experiencing stress, since it appears that a constituent part of the bodily stress response remains exclusively designed to be effective in a hot tropical environment, where the stress can be expected to be accompanied by thermoregulation sweating and an overheated body. For without such an occurrence coinciding with stress, the stress response itself appears to have been transposed into a reaction that inhibits the body's ability to resist infection and disease.

摘要

这一假说表明,心理社会压力是许多现代疾病的关键决定因素,其后果是摄入了当今的抗坏血酸和钠的营养成分。因为,由于我们在热带非洲的进化,当身体受到任何形式的压力时,当今这些必需营养素的摄入量似乎与维持身体内环境稳定不相容。此外,我们大多数人生活的气候条件似乎不适合承受压力,因为身体应激反应的一个组成部分似乎专门设计用于在炎热的热带环境中发挥作用,在这种环境中,压力可能伴随着体温调节出汗和身体过热。因为如果没有这种与压力同时发生的情况,应激反应本身似乎就会转变为一种抑制身体抵抗感染和疾病能力的反应。

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