Drummond R
Med Hypotheses. 1994 Sep;43(3):160-2. doi: 10.1016/0306-9877(94)90144-9.
In a recent paper it was argued that all stem cells are small motile cells, the haemopoietic stem cell being no exception. Although haemopoietic stem cells arise and mature in an extravascular milieu, they are present in small numbers in the peripheral circulation, where they have a lymphocyte-like appearance, and in the peripheral circulation their fate can be linked to the development of basophils. The basophil is a cell shrouded in mystery, and one of the most mysterious aspects of the basophil is its small numbers in bone marrow, a finding which does not fit in with a marrow origin. A simple experiment provides an alternative explanation as to how they develop. If peripheral blood smears are prevented from drying out, after a few hours new basophils develop from a lymphocyte-like cell. The findings suggest that the basophil may arise, not in the marrow, but in the peripheral circulation, and may represent an aberrant development of the haemopoietic stem cell caused by the plasma. The pathology of the basophil supports this view.
在最近的一篇论文中，有人认为所有干细胞都是小型运动细胞，造血干细胞也不例外。尽管造血干细胞在血管外环境中产生并成熟，但它们少量存在于外周循环中，在外周循环中它们具有类似淋巴细胞的外观，并且在外周循环中它们的命运可能与嗜碱性粒细胞的发育有关。嗜碱性粒细胞是一种笼罩在神秘之中的细胞，而嗜碱性粒细胞最神秘的方面之一是其在骨髓中的数量很少，这一发现与骨髓起源不符。一个简单的实验为它们的发育方式提供了另一种解释。如果防止外周血涂片干燥，几小时后会从类似淋巴细胞的细胞中产生新的嗜碱性粒细胞。这些发现表明，嗜碱性粒细胞可能并非起源于骨髓，而是起源于外周循环，并且可能代表由血浆引起的造血干细胞的异常发育。嗜碱性粒细胞的病理学支持这一观点。
