Oetjen Landon K, Noti Mario, Kim Brian S
Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA.
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.
Semin Immunopathol. 2016 Sep;38(5):549-61. doi: 10.1007/s00281-016-0567-z. Epub 2016 May 13.
Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.
嗜碱性粒细胞已越来越被视为介导抗蠕虫免疫和屏障炎症的重要天然免疫细胞。最近的发现揭示了嗜碱性粒细胞群体中以前未被认识到的异质性。然而，嗜碱性粒细胞调节和功能的多样性如何影响人类疾病仍不清楚。本综述的目的是强调对嗜碱性粒细胞异质性的新见解如何能帮助我们更好地理解疾病发病机制并为新疗法的开发提供信息。
