嗜碱性粒细胞异质性的新见解。
New insights into basophil heterogeneity.
作者信息
Oetjen Landon K, Noti Mario, Kim Brian S
机构信息
Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA.
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Semin Immunopathol. 2016 Sep;38(5):549-61. doi: 10.1007/s00281-016-0567-z. Epub 2016 May 13.
Abstract
Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.
摘要
嗜碱性粒细胞已越来越被视为介导抗蠕虫免疫和屏障炎症的重要天然免疫细胞。最近的发现揭示了嗜碱性粒细胞群体中以前未被认识到的异质性。然而，嗜碱性粒细胞调节和功能的多样性如何影响人类疾病仍不清楚。本综述的目的是强调对嗜碱性粒细胞异质性的新见解如何能帮助我们更好地理解疾病发病机制并为新疗法的开发提供信息。
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本文引用的文献
1
Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain.天然嗜碱性粒细胞对过敏原、内毒素和细胞因子的白细胞介素-4反应需要Fc受体γ链。
J Allergy Clin Immunol. 2016 May;137(5):1613-1615.e2. doi: 10.1016/j.jaci.2015.10.037. Epub 2015 Dec 17.
2
Mouse and human FcR effector functions.鼠类和人类 FcR 效应功能。
Immunol Rev. 2015 Nov;268(1):25-51. doi: 10.1111/imr.12350.
3
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.度普利尤单抗治疗外用药物治疗控制不佳的中重度特应性皮炎成人患者的疗效和安全性：一项随机、安慰剂对照、剂量范围的 2b 期临床试验。
Lancet. 2016 Jan 2;387(10013):40-52. doi: 10.1016/S0140-6736(15)00388-8. Epub 2015 Oct 8.
4
Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases.慢性炎症性疾病中嗜碱性粒细胞与T细胞的相互作用
Front Immunol. 2015 Aug 3;6:399. doi: 10.3389/fimmu.2015.00399. eCollection 2015.
5
Barrier Epithelial Cells and the Control of Type 2 Immunity.屏障上皮细胞与 2 型免疫的调控。
Immunity. 2015 Jul 21;43(1):29-40. doi: 10.1016/j.immuni.2015.07.007.
6
Eosinophilic Esophagitis: A Comprehensive Review.嗜酸性食管炎：综合综述
Clin Rev Allergy Immunol. 2016 Apr;50(2):159-74. doi: 10.1007/s12016-015-8501-z.
7
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Science. 2015 Aug 28;349(6251):989-93. doi: 10.1126/science.aac4263. Epub 2015 Jul 9.
8
Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.组织稳态、损伤与炎症中的白细胞介素-33
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9
Basophils in inflammation.炎症中的嗜碱性粒细胞。
Eur J Pharmacol. 2016 May 5;778:90-5. doi: 10.1016/j.ejphar.2015.04.049. Epub 2015 May 7.
10
Protective Role of STAT6 in Basophil-Dependent Prurigo-like Allergic Skin Inflammation.
J Immunol. 2015 May 15;194(10):4631-40. doi: 10.4049/jimmunol.1401032. Epub 2015 Apr 10.
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