Partonen T
University Central Hospital, Department of Psychiatry, Helsinki, Finland.
Med Hypotheses. 1994 Sep;43(3):165-6. doi: 10.1016/0306-9877(94)90146-5.
The phase of circadian rhythms can be shifted by exposure to light. Most patients with winter depression are suggested to have a phase delay in their circadian rhythms. The efficacy of light in treatment of winter depression is thought to be associated with the phase shifting effect of light. In addition to light, melatonin and serotonin can cause phase shifts of the rhythms. The concerted action of these indoleamines may underly the finding that light has an antidepressant effect, independently of time of day or circadian phase of an individual.
昼夜节律的相位可通过光照而发生改变。大多数冬季抑郁症患者被认为其昼夜节律存在相位延迟。光照治疗冬季抑郁症的疗效被认为与光照的相位移动效应有关。除了光照，褪黑素和血清素也可引起节律的相位改变。这些吲哚胺的协同作用可能是光照具有抗抑郁作用这一发现的基础，而与一天中的时间或个体的昼夜相位无关。
