冬季抑郁嗜睡患者在持续日常活动期间的暗光褪黑素起始时间和昼夜节律体温

Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression.

作者信息

Dahl K, Avery D H, Lewy A J, Savage M V, Brengelmann G L, Larsen L H, Vitiello M V, Prinz P N

机构信息

Department of Psychology, University of Washington, Seattle.

出版信息

Acta Psychiatr Scand. 1993 Jul;88(1):60-6. doi: 10.1111/j.1600-0447.1993.tb03414.x.

DOI:10.1111/j.1600-0447.1993.tb03414.x

PMID:8372697

Abstract

The onset of melatonin secretion under dim light conditions (DLMO) and the circadian temperature rhythm during a constant routine were assessed in 6 female controls and 6 female patients with winter depression (seasonal affective disorder, SAD) before and after bright light treatment. After sleep was standardized for 6 days, the subjects were sleep-deprived and at bedrest for 27 h while core temperature and evening melatonin levels were determined. The DLMO of the SAD patients was phase-delayed compared with controls (2310 vs 2138); with bright light treatment, the DLMO advanced (2310 to 2135). The minimum of the fitted rectal temperature rhythm was phase-delayed in the SAD group compared with the controls (0542 vs 0316); with bright light treatment, the minimum advanced (0542 vs 0336).

摘要

在明亮光疗前后，对6名女性对照者和6名患有冬季抑郁症（季节性情感障碍，SAD）的女性患者在暗光条件下褪黑素分泌的开始时间（DLMO）和持续日常活动期间的昼夜体温节律进行了评估。在将睡眠标准化6天后，让受试者睡眠剥夺并卧床休息27小时，同时测定核心体温和夜间褪黑素水平。与对照组相比，SAD患者的DLMO相位延迟（23:10对21:38）；经过明亮光疗后，DLMO提前（23:10至21:35）。与对照组相比，SAD组拟合直肠温度节律的最低点相位延迟（05:42对03:16）；经过明亮光疗后，最低点提前（05:42对03:36）。