Nakhoul F, Kerner H, Levin M, Best L A, Better O S
Department of Nephrology, Rambam Hospital, Haifa, Israel.
Miner Electrolyte Metab. 1994;20(3):107-11.
The clinical and laboratory data, and histologic, electron microscopic and immunocytochemical findings of a carcinoid tumor of the lung associated with parathyroid hyperplasia and persistent hypercalcemia are described. The carcinoid tumor consists of uniform cuboidal cells with regular round vesicular nuclei and eosinophilic granular cytoplasm. The tumor cells were chromogranin and neuron-specific enolase positive. The CAT scan of the abdomen revealed an adrenal mass, 3 cm in diameter, and an enlarged body in the pancreas. Our patient is still suffering from hypercalcemia and renal colic, despite repeated parathyroid gland removal, and enucleation of the lung mass. Recent parathyroid scintigraphy with Tc revealed an enlarged parathyroid gland. The thoracic CAT scan is normal. We believe that our patient is suffering from multiple endocrine neoplasia type-1 with persistent hypercalcemia due to hyperparathyroidism.
描述了一例与甲状旁腺增生和持续性高钙血症相关的肺类癌肿瘤的临床和实验室数据，以及组织学、电子显微镜和免疫细胞化学检查结果。类癌肿瘤由均匀的立方体细胞组成，细胞核呈规则的圆形泡状，细胞质嗜酸性且呈颗粒状。肿瘤细胞嗜铬粒蛋白和神经元特异性烯醇化酶呈阳性。腹部计算机断层扫描（CAT）显示一个直径3厘米的肾上腺肿块和胰腺肿大。尽管多次切除甲状旁腺并摘除肺部肿块，但我们的患者仍患有高钙血症和肾绞痛。最近用锝进行的甲状旁腺闪烁扫描显示甲状旁腺肿大。胸部CAT扫描正常。我们认为我们的患者患有1型多发性内分泌肿瘤，因甲状旁腺功能亢进导致持续性高钙血症。
