Matsuda Kant M, Nóbrega Raíssa, Quezado Martha, Schrump David S, Filie Armando C
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Diagn Cytopathol. 2010 Sep;38(9):669-74. doi: 10.1002/dc.21296.
We present the cytological features along with histologic and imaging findings of a melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1 (MEN-1). Intraoperative touch preparations of the lung tumor showed single spindle cells and loosely cohesive aggregates of spindle cells with oval to elongated nuclei, "salt and pepper" chromatin pattern and inconspicuous nucleoli. The spindle cells occasionally contained cytoplasmic pigment, which revealed to be melanin by Fontana Masson stain on permanent processed material. Immunohistochemical stains for both synaptophysin and chromogranin were strongly positive in the spindle cells. The findings were consistent with melanocytic bronchopulmonary carcinoid tumor, which is relatively uncommon in MEN-1.
我们展示了一名患有1型多发性内分泌肿瘤综合征（MEN-1）患者的黑素细胞性支气管肺类癌肿瘤的细胞学特征以及组织学和影像学表现。肺肿瘤的术中触摸涂片显示单个梭形细胞以及梭形细胞的松散聚集，细胞核呈椭圆形至细长形，染色质呈“椒盐”样，核仁不明显。梭形细胞偶尔含有细胞质色素，经永久性处理材料上的Fontana Masson染色显示为黑色素。突触素和嗜铬粒蛋白的免疫组织化学染色在梭形细胞中均呈强阳性。这些发现与黑素细胞性支气管肺类癌肿瘤一致，该肿瘤在MEN-1中相对少见。
