Capecchi M, Ficarra G, Pagni L
Istituto di Odonto-Gnato-Stomatologia, USL 10/D, Università di Firenze.
Minerva Stomatol. 1994 Sep;43(9):423-8.
Benign mucous membrane pemphigoid is an autoimmune vesiculo-bullous disease which affects the oral mucosa. The purpose of this study is to report the clinical and pathological features of 20 patients with benign mucous membrane pemphigoid. Four patients were men and 16 female with a mean age of 58 years. The ratio of male to female was 1:4. Seventy percent of patients showed gingival involvement. Other locations were buccal mucosa, palate and floor of the mouth. The majority of patients had ulcers covered by pseudomembranes, complained of pain and burning and 40% reported bleeding gums. Nikolsky's sign was observed in 60% of cases. In all cases microscopic features of benign mucous membrane pemphigoid showed a separation of epithelium from the connective tissue along the basement membrane (sub-epithelial bulla).
良性黏膜类天疱疮是一种影响口腔黏膜的自身免疫性水疱大疱性疾病。本研究的目的是报告20例良性黏膜类天疱疮患者的临床和病理特征。4例为男性，16例为女性，平均年龄58岁。男女比例为1:4。70%的患者有牙龈受累。其他部位为颊黏膜、腭部和口底。大多数患者有被假膜覆盖的溃疡，主诉疼痛和烧灼感，40%的患者报告牙龈出血。60%的病例观察到尼氏征。在所有病例中，良性黏膜类天疱疮的微观特征显示上皮沿基底膜与结缔组织分离（上皮下大疱）。
