Eilers J, Augustine G J, Konnerth A
I. Physiologisches Institut, Universität des Saarlandes, Homburg, Germany.
Nature. 1995 Jan 12;373(6510):155-8. doi: 10.1038/373155a0.
The conventional view of synaptic integration is that it results from the simple summation of electrical signals produced by each active synapse innervating a given neuron. However, because synaptic action can go beyond the production of postsynaptic electrical signals, to include intracellular biochemical events such as the generation of second messengers, it is possible that synaptic integration could occur at another level. We have considered this possibility by examining changes in the dendritic concentration of the second messenger, calcium, resulting from subthreshold excitatory synaptic activity in cerebellar Purkinje neurons. We report here clear evidence that such non-electrical synaptic integration occurs and that it takes place in restricted dendritic compartments consisting of spines and adjacent fine dendrites.
传统的突触整合观点认为，它是由支配给定神经元的每个活跃突触产生的电信号简单总和所导致的。然而，由于突触作用可以超越突触后电信号的产生，包括细胞内生化事件，如第二信使的生成，所以突触整合有可能在另一个层面发生。我们通过研究小脑浦肯野神经元阈下兴奋性突触活动所导致的第二信使钙在树突中的浓度变化，来探讨这种可能性。我们在此报告明确的证据，表明这种非电突触整合确实发生，并且它发生在由棘突和相邻细树突组成的受限树突区域。
