比芬美兰对普通狨猴中由1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森症的影响。

Effects of bifemelane on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset.

作者信息

Nomoto M, Irifune M, Fukuzaki K, Fukuda T

机构信息

Department of Pharmacology, Kagoshima University School of Medicine, Japan.

出版信息

Neurosci Lett. 1994 Aug 29;178(1):95-8. doi: 10.1016/0304-3940(94)90298-4.

DOI:10.1016/0304-3940(94)90298-4

PMID:7816348

Abstract

The effects of bifemelane on parkinsonism were shown in MPTP-treated common marmosets. The administration of bifemelane increased locomotor activity in MPTP-treated marmosets but not in normal control marmosets. In a microdialysis study, extracellular levels of dopamine and its metabolites increased following the administration of bifemelane. These results indicate that it is worth studying the effects of bifemelane hydrochloride on patients with Parkinson's disease.

摘要

双苯美仑对帕金森症的影响在经1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）处理的普通狨猴中得到了证实。给予双苯美仑可增加经MPTP处理的狨猴的运动活性，但对正常对照狨猴则无此作用。在一项微透析研究中，给予双苯美仑后，多巴胺及其代谢产物的细胞外水平升高。这些结果表明，研究盐酸双苯美仑对帕金森病患者的影响是值得的。