Shively M L, Dec S F
Atrix Laboratories, Inc., Fort Collins, CO 80525.
Pharm Res. 1994 Sep;11(9):1301-5. doi: 10.1023/a:1018946512445.
The molecular environment of sucrose and mineral oil within sucrose and mineral oil solid state emulsions was investigated by NMR techniques. The 13C and 1H chemical shifts of sucrose and mineral oil to those observed in solid state emulsions (comprised of sucrose and mineral oil) were equivalent, indicating that the local structure of sucrose is unaffected by the presence of mineral oil in the solid-state emulsion. Cross-polarization, magic angle spinning 13C (CP-MAS) in conjunction with single-pulse studies indicated that the 1H-13C dipole-dipole interactions are very weak, i.e., mineral oil is highly mobile. Spinning side bands were observed, however, in 1H single-pulse, magic angle spinning (SPMAS) spectra of the solid-state emulsion, indicating that the mineral oil has solid properties. Although the mineral oil was shown to be highly mobile, it also appears to be constrained or included by the sucrose.
采用核磁共振技术研究了蔗糖和矿物油固态乳液中蔗糖和矿物油的分子环境。蔗糖和矿物油在固态乳液（由蔗糖和矿物油组成）中的13C和1H化学位移与观测到的化学位移相当，这表明固态乳液中矿物油的存在并未影响蔗糖的局部结构。交叉极化、魔角旋转13C（CP-MAS）结合单脉冲研究表明，1H-13C偶极-偶极相互作用非常弱，即矿物油具有高度流动性。然而，在固态乳液的1H单脉冲魔角旋转（SPMAS）谱中观察到了旋转边带，这表明矿物油具有固体性质。尽管矿物油显示出高度的流动性，但它似乎也受到蔗糖的限制或包含在蔗糖之中。
