Wan F J, Geyer M A, Swerdlow N R
Department of Neuroscience, UCSD School of Medicine, La Jolla 92093-0804.
Pharmacol Biochem Behav. 1994 Sep;49(1):155-63. doi: 10.1016/0091-3057(94)90470-7.
The normal reduction in acoustic startle amplitude caused by a weak prepulse (prepulse inhibition; PPI) is deficient in schizophrenic patients and in rats after systemic or intraaccumbens treatment with the D2 dopamine agonist quinpirole. We examined the anatomical substrates of the PPI-disruptive effects of intraaccumbens quinpirole. PPI was significantly reduced in a dose-dependent manner by quinpirole infusion into the medial accumbens shell region, the lateral accumbens core region, and an intermediate central region. There was a weak tendency for this quinpirole effect to be more pronounced in core and central accumbens regions than in the medial and anteromedial accumbens. Using the retrograde tracer Nuclear yellow, shell and core regions were verified to receive different patterns of limbic cortical innervation. Although the accumbens appears to have a complex and functionally diversified intrinsic anatomy, the accumbens D2 modulation of sensorimotor gating appears to be distributed across several different accumbens subregions.
由弱预脉冲引起的听觉惊跳幅度正常降低（预脉冲抑制；PPI）在精神分裂症患者以及用D2多巴胺激动剂喹吡罗进行全身或伏隔核内治疗后的大鼠中存在缺陷。我们研究了伏隔核内喹吡罗破坏PPI作用的解剖学基质。向伏隔核内侧壳区、外侧伏隔核核心区和中间中央区注入喹吡罗，PPI以剂量依赖方式显著降低。喹吡罗的这种作用在伏隔核核心区和中央区比在内侧和前内侧伏隔核更明显，不过这种趋势较弱。使用逆行示踪剂核黄，证实壳区和核心区接受不同模式的边缘皮质神经支配。虽然伏隔核似乎具有复杂且功能多样的内在解剖结构，但伏隔核D2对感觉运动门控的调节似乎分布在几个不同的伏隔核亚区。
