Rowlett J K, Gibson T R, Bardo M T
Department of Psychology, University of Kentucky, Lexington 40506-0044.
Pharmacol Biochem Behav. 1994 Sep;49(1):241-5. doi: 10.1016/0091-3057(94)90484-7.
The locomotor and rewarding effects of the opioid mixed agonist-antagonist buprenorphine were assessed in a conditioned place preference (CPP) experiment. Separate groups of rats were given one of three doses of buprenorphine (0.3, 1.0 or 3.0 mg/kg) or saline paired with the white compartment of a CPP apparatus. The following day, all rats received saline paired with the black compartment. After six conditioning trials, rats were given free access to all compartments of the CPP apparatus. Horizontal activity data obtained during conditioning revealed increased activity (i.e., behavioral sensitization) for the three doses on trial 6. Vertical activity data revealed significant increases on trial 6 for the 1.0 and 3.0 mg/kg doses only. Significant CPP was obtained with the 0.3 mg/kg and 1.0 mg/kg doses of buprenorphine, but not with the 3.0 mg/kg dose. These data indicate that buprenorphine elicits locomotor sensitization after repeated exposures that follows a linear dose-response relationship. In contrast, these data suggest that the rewarding effects of buprenorphine follow an inverted U-shaped dose-response curve.
在条件性位置偏爱（CPP）实验中评估了阿片类混合激动剂-拮抗剂丁丙诺啡的运动和奖赏效应。将单独的几组大鼠给予三种剂量之一的丁丙诺啡（0.3、1.0或3.0毫克/千克）或生理盐水，并与CPP装置的白色隔室配对。第二天，所有大鼠接受与黑色隔室配对的生理盐水。经过六次条件训练试验后，让大鼠自由进入CPP装置的所有隔室。在条件训练期间获得的水平活动数据显示，在第6次试验时，三种剂量的大鼠活动均增加（即行为敏化）。垂直活动数据显示，仅在第6次试验时，1.0毫克/千克和3.0毫克/千克剂量的大鼠活动显著增加。0.3毫克/千克和1.0毫克/千克剂量的丁丙诺啡可产生显著的CPP，但3.0毫克/千克剂量则不然。这些数据表明，丁丙诺啡在反复暴露后会引发运动敏化，且呈线性剂量-反应关系。相比之下，这些数据表明丁丙诺啡的奖赏效应遵循倒U形剂量-反应曲线。
