Gaiardi M, Bartoletti M, Bacchi A, Gubellini C, Babbini M
Department of Pharmacology, University of Bologna, Italy.
Psychopharmacology (Berl). 1997 Mar;130(2):104-8. doi: 10.1007/s002130050216.
Buprenorphine, a mixed agonist-antagonist opioid with considerable analgesic activity, is currently indicated as a therapeutic agent with low abuse potential. Nevertheless, buprenorphine abuse has been recently reported from some countries. Thus the present experiments were performed to characterize further the motivational properties of buprenorphine in rats. Rewarding and aversive effects were assessed by place preference and taste aversion conditioning, respectively. It was found that buprenorphine (0.025, 0.050, 0.100 mg/kg s.c.) causes a significant increase in the amount of time spent on the conditioned side, but no significant decrease in saccharin consumption. Therefore buprenorphine data are not consistent with the general finding that psychoactive drugs cause rewarding and aversive effects within a similar dose range.
丁丙诺啡是一种具有相当镇痛活性的混合激动-拮抗型阿片类药物，目前被用作滥用可能性较低的治疗药物。然而，最近一些国家报道了丁丙诺啡滥用的情况。因此，进行了本实验以进一步表征丁丙诺啡在大鼠中的动机特性。分别通过位置偏爱和味觉厌恶条件反射评估奖赏和厌恶效应。结果发现，丁丙诺啡（0.025、0.050、0.100毫克/千克，皮下注射）使在条件化一侧停留的时间显著增加，但糖精消耗量没有显著减少。因此，丁丙诺啡的数据与精神活性药物在相似剂量范围内产生奖赏和厌恶效应的一般发现不一致。
