合成羟基查耳酮的抗念珠菌活性。
Anti-Candida activity of synthetic hydroxychalcones.
作者信息
Tsuchiya H, Sato M, Akagiri M, Takagi N, Tanaka T, Iinuma M
机构信息
Department of Dental Pharmacology, Asahi University School of Dentistry, Gifu, Japan.
出版信息
Pharmazie. 1994 Oct;49(10):756-8.
PMID:7816901
Abstract
The antifungal activity of different synthetic hydroxychalcones was determined against Candida species. It was revealed that the presence of hydroxyl groups at C-2, C-4, and C-2' in chalcone was essential to inhibit Candida growth. Among the chalcone derivatives examined, 2,4,2'-trihydroxy-5'-methylchalcone showed the most intensive anti-Candida activity, suggesting that it could be a potential therapeutic agent for candidosis.
摘要
测定了不同合成羟基查耳酮对念珠菌属的抗真菌活性。结果表明，查耳酮中C-2、C-4和C-2'位存在羟基对于抑制念珠菌生长至关重要。在所检测的查耳酮衍生物中，2,4,2'-三羟基-5'-甲基查耳酮表现出最强的抗念珠菌活性，表明它可能是一种潜在的念珠菌病治疗药物。
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