ElSohly H N, Joshi A S, Nimrod A C, Walker L A, Clark A M
Planta Med. 2001 Feb;67(1):87-9. doi: 10.1055/s-2001-10621.
Five prenylated flavonoids, including one new natural product, were isolated from an ethanol extract of the leaves of Maclura tinctoria (L.) Gaud. The new compound has been characterized as 2',4',4,2''-tetrahydroxy-3'-[3''-methylbut-3''-enyl]chalcone (1). The known compounds were identified as 2',4',4-trihydroxy-3'-[3''-methylbut-3''-enyl]chalcone (isobavachalcone) (2), 4,2'-dihydroxy-2''-[1-hydroxy-1-methylethyl]-2'',3''-dihydrofurano[4'',5'':3',4']chalcone (bakuchalcone) (3), 4,4',5''-trihydroxy-6'',6''-dimethyldihydropyrano[2'',3'':5',6'']chalcone (bavachromanol) (4), and 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (6,8-diprenylorobol) (5). All the isolated compounds were evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. Compound 2 was active against both yeasts.
从染料桑（Maclura tinctoria (L.) Gaud.）叶的乙醇提取物中分离出5种异戊烯基黄酮类化合物，其中包括1个新的天然产物。该新化合物已被鉴定为2',4',4,2''-四羟基-3'-[3''-甲基丁-3''-烯基]查耳酮（1）。已知化合物被鉴定为2',4',4-三羟基-3'-[3''-甲基丁-3''-烯基]查耳酮（异补骨脂查耳酮）（2）、4,2'-二羟基-2''-[1-羟基-1-甲基乙基]-2'',3''-二氢呋喃并[4'',5'':3',4']查耳酮（补骨脂查耳酮）（3）、4,4',5''-三羟基-6'',6''-二甲基二氢吡喃并[2'',3'':5',6'']查耳酮（补骨脂色原烷醇）（4）和5,7,3',4'-四羟基-6,8-二异戊烯基异黄酮（6,8-二异戊烯基奥洛波醇）（5）。对所有分离得到的化合物针对与艾滋病相关的机会性真菌病原体白色念珠菌和新型隐球菌进行了评估。化合物2对这两种酵母均有活性。
