Kovacs D A, Zoll J G
Pharmacol Biochem Behav. 1976 May;4(5):621-5. doi: 10.1016/0091-3057(76)90208-2.
An intracerebral chemitrode is described for infusion and recovery of solutes as well as stimulation and recording of discrete brain loci. The chemitrode consists of two insulated tubes in juxtaposition with implantable angular ends faced together and covered with a high porosity polycarbonate Nuclepore membrane so as to create a sealed, nonclogging, perfusion chamber. Electrical connectors are affixed directly to the tubes at the external end for stimulating and recording of the perfusion area. Experiments showing electrical stimulation of the chemitrode to produce epileptic foci at the site of perfusion, infusion of drugs to produce changes in brain activity and extraction of ethanol following peripheral injection demonstrate the potential utility of the chemitrode in a wide variety of neurobiological problems.
本文描述了一种用于溶质注入和回收以及离散脑区刺激和记录的脑内化学电极。该化学电极由两根绝缘管并列组成，其可植入的角形末端相对，并用高孔隙率聚碳酸酯核孔膜覆盖，从而形成一个密封、不堵塞的灌注腔室。电连接器直接固定在管的外端，用于刺激和记录灌注区域。实验表明，对化学电极进行电刺激可在灌注部位产生癫痫病灶，注入药物可引起脑活动变化，外周注射后可提取乙醇，这些都证明了该化学电极在多种神经生物学问题中的潜在应用价值。
