Onuma T, Kikuchi T, Shimura M, Tsutsui M, Matsui J, Boku A, Takebe K
Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
Tohoku J Exp Med. 1994 Jun;173(2):209-16. doi: 10.1620/tjem.173.209.
Relationship of the lipoprotein(a) [Lp(a)] concentration as a risk factor independent of other factors with the severity of diabetic retinopathy were evaluated by multiple regression analysis. The subjects were 158 patients with non-insulin-dependent diabetes mellitus (NIDDM). Multiple regression analysis was carried with the severity of diabetic retinopathy as the dependent variable and 13 independent variables, namely the Lp(a) concentration, sex, age, body mass index, duration of diabetes, ischemic heart disease, fasting plasma glucose, glycosylated hemoglobin A1c, total cholesterol, triglyceride, high-density lipoprotein cholesterol, anti-diabetic treatments, and diabetic nephropathy. The analysis was performed separately in all subjects, males only, and females only. The standard partial regression coefficient of Lp(a) was significant (0.293, p < 0.01), and the multiple correlation coefficient was 0.611 in the males. However, the standard partial correlation coefficient of Lp(a) was not significant in all patients and in females only. The rank of contribution of Lp(a) to retinopathy was the third in males, following triglyceride and nephropathy and followed by anti-diabetic treatments. These results suggest that Lp(a) might be an independent risk factor for diabetic retinopathy in male patients with NIDDM.
通过多元回归分析评估脂蛋白(a)[Lp(a)]浓度作为独立于其他因素的危险因素与糖尿病视网膜病变严重程度之间的关系。研究对象为158例非胰岛素依赖型糖尿病(NIDDM)患者。以糖尿病视网膜病变的严重程度为因变量，以Lp(a)浓度、性别、年龄、体重指数、糖尿病病程、缺血性心脏病、空腹血糖、糖化血红蛋白A1c、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、抗糖尿病治疗及糖尿病肾病等13个自变量进行多元回归分析。分析分别在所有受试者、仅男性受试者和仅女性受试者中进行。在男性中，Lp(a)的标准偏回归系数显著(0.293，p<0.01)，复相关系数为0.611。然而，Lp(a)的标准偏相关系数在所有患者及仅女性患者中不显著。在男性中，Lp(a)对视网膜病变的贡献排名第三，仅次于甘油三酯和肾病，其次是抗糖尿病治疗。这些结果表明，Lp(a)可能是男性NIDDM患者糖尿病视网膜病变的独立危险因素。
