Student Research Committee, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
Diab Vasc Dis Res. 2023 Nov-Dec;20(6):14791641231197114. doi: 10.1177/14791641231197114.
BACKGROUND: Lipoprotein a (LP(a)), an LDL-like lipoprotein, known as a risk factor for cardiovascular diseases, has a controversial association with diabetic retinopathy in patients with type 2 diabetes-the current systematic review aimed to critically assess the association between LP(a) and diabetic retinopathy. METHODS: A systematic review of relevant studies was conducted after a thorough search in PubMed, Scopus, and Google Scholar electronic databases. We used English observational, case-control, and prospective cohort studies published up to August 2022, including type 2 diabetic patients as the population, diabetic retinopathy as the outcome, and LP(a) as the intervention. RESULT: 17 relevant studies, including 4688 patients with diabetes, were included in this systematic review. While in 13 studies, Lipoprotein(a) was recognized as a risk factor for diabetic retinopathy, only three studies reported no evidence of a relationship between the two. Also, another study showed a mixed outcome of the relationship between LP(a) and diabetic retinopathy. CONCLUSION: High serum lipoprotein(a) in patients with type 2 diabetes is considered a risk factor for diabetic retinopathy. However, further large-scaled cohort studies are still required to validate this finding.
背景：脂蛋白(a)（LP(a)）是一种 LDL 样脂蛋白，被认为是心血管疾病的危险因素，它与 2 型糖尿病患者的糖尿病视网膜病变之间的关系存在争议——本次系统评价旨在批判性地评估 LP(a)与糖尿病视网膜病变之间的关系。
方法：在 PubMed、Scopus 和 Google Scholar 电子数据库中进行全面检索后，对相关研究进行了系统评价。我们使用了截至 2022 年 8 月发表的英文观察性、病例对照和前瞻性队列研究，包括 2 型糖尿病患者作为研究人群、糖尿病视网膜病变作为结局、LP(a)作为干预措施。
结果：本系统评价共纳入了 17 项相关研究，共纳入了 4688 例糖尿病患者。其中 13 项研究认为脂蛋白(a)是糖尿病视网膜病变的危险因素，但只有 3 项研究未发现两者之间存在关联。此外，另一项研究显示 LP(a)与糖尿病视网膜病变之间的关系存在混合结果。
结论：在 2 型糖尿病患者中，血清脂蛋白(a)水平升高被认为是糖尿病视网膜病变的危险因素。然而，仍需要进一步的大规模队列研究来验证这一发现。
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