Yamamoto T, Kimura T, Ota K, Shoji M, Inoue M, Ohta M, Sato K, Funyu T, Abe K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1994 Jun;173(2):231-45. doi: 10.1620/tjem.173.231.
To assess how interleukins (IL) affect the release of vasopressin (AVP), atrial natriuretic hormone (ANH), and ACTH and the regulation of blood pressure (BP), heart rate (HR) and rectal temperature (RT), the 3 doses of 1.73 (low dose, LD), 8.63 (medium dose, MD), and 43.16 pmol/100 gBW (high dose, HD) of human recombinant IL-1 beta were intravenously (iv) administered in conscious rats, and plasma AVP, ANH, and ACTH, BP, HR and RT were determined simultaneously. In the control group (CON), the drug was omitted. Circulatory IL-1 beta levels were determined in each dose, and indomethacin (1 mg/rat, IM) was administered iv in the HD and CON groups. Plasma IL-1 beta increased transiently following IL-1 beta administration in each group. Plasma AVP, ANH, and ACTH increased in the LD, MD, and HD groups, respectively. Mean arterial BP (MABP) and RT increased in the LD group, but HR did not change. In the MD and HD groups, MABP decreased at 30 min followed by its increase at 120 min, but RT in both groups decreased. In the CON group, these parameters did not change. IM attenuated plasma AVP and ACTH responses to HD and also inhibited decreases in MABP and RT. These results suggest that IL-1 beta affects the release of AVP and ACTH, blood pressure and thermogenesis via prostaglandins (PGs), but ANH release related to IL-1 beta may not be mediated by PGs.
为了评估白细胞介素（IL）如何影响血管加压素（AVP）、心房利钠肽（ANH）和促肾上腺皮质激素（ACTH）的释放以及血压（BP）、心率（HR）和直肠温度（RT）的调节，将3种剂量（1.73 pmol/100 g体重，低剂量，LD；8.63 pmol/100 g体重，中剂量，MD；43.16 pmol/100 g体重，高剂量，HD）的重组人IL-1β静脉注射到清醒大鼠体内，并同时测定血浆AVP、ANH、ACTH、BP、HR和RT。对照组（CON）不注射药物。测定每组循环中的IL-1β水平，并在HD组和CON组静脉注射吲哚美辛（1 mg/只，肌肉注射）。每组注射IL-1β后血浆IL-1β短暂升高。LD组、MD组和HD组血浆AVP、ANH和ACTH分别升高。LD组平均动脉压（MABP）和RT升高，但HR未改变。MD组和HD组在30分钟时MABP降低，随后在120分钟时升高，但两组的RT均降低。CON组这些参数无变化。肌肉注射减弱了血浆AVP和ACTH对HD的反应，也抑制了MABP和RT的降低。这些结果表明，IL-1β通过前列腺素（PGs）影响AVP和ACTH的释放、血压和产热，但与IL-1β相关的ANH释放可能不是由PGs介导的。
