Bandler R, Shipley M T
Dept of Anatomy and Histology, University of Sydney, New South Wales, Australia.
Trends Neurosci. 1994 Sep;17(9):379-89. doi: 10.1016/0166-2236(94)90047-7.
Independent discoveries in several laboratories suggest that the midbrain periaqueductal gray (PAG), the cell-dense region surrounding the midbrain aqueduct, contains a previously unsuspected degree of anatomical and functional organization. This organization takes the form of longitudinal columns of afferent inputs, output neurons and intrinsic interneurons. Recent evidence suggests: that the important functions that are classically associated with the PAG--defensive reactions, analgesia and autonomic regulation--are integrated by overlapping longitudinal columns of neurons; and that different classes of threatening or nociceptive stimuli trigger distinct co-ordinated patterns of skeletal, autonomic and antinociceptive adjustments by selectively targeting specific PAG columnar circuits. These findings call for a fundamental revision in our concept of the organization of the PAG, and a recognition of the special roles played by different longitudinal PAG columns in co-ordinating distinct strategies for coping with different types of stress, threat and pain.
多个实验室的独立研究发现表明，中脑导水管周围灰质（PAG），即围绕中脑导水管的细胞密集区域，具有此前未被怀疑的解剖学和功能组织程度。这种组织形式表现为传入输入、输出神经元和内在中间神经元的纵向柱。最近的证据表明：经典上与PAG相关的重要功能——防御反应、镇痛和自主调节——是由重叠的神经元纵向柱整合的；不同类型的威胁性或伤害性刺激通过选择性地靶向特定的PAG柱状回路，触发骨骼、自主和抗伤害性调整的不同协调模式。这些发现要求我们对PAG的组织概念进行根本性修订，并认识到不同的PAG纵向柱在协调应对不同类型压力、威胁和疼痛的不同策略中所起的特殊作用。
