Hensler M K, Forrest M, Lorentzen J E, Schroeder T V
Karkirurgisk afdeling RK, Rigshospitalet, København.
Ugeskr Laeger. 1994 Nov 21;156(47):7043-7.
The purpose of the study was to evaluate the effect of surgery for renal artery stenosis in patients with impaired renal function. The design was a retrospective investigation with follow-up. The material consisted of 42 such patients operated at Rigshospitalet between 1980 and 1990. Renal function and blood pressure status was evaluated preoperatively and at follow-up. The perioperative mortality was 5% (n = 2) and morbidity 21% (n = 9). At discharge from hospital renal function was maintained in 38 patients (90%), including three patients who at the time of operation were without diuresis and had been in dialysis for up to 28 days. Twenty-three patients were still alive at postoperative follow-up at a median of 66 months. The cumulative five-year survival was 62%, which was significantly lower than that of a sex- and age-matched population. Eleven patients developed terminal renal insufficiency during the follow-up period. The cumulative preservation of renal function was 77% after five years. In conclusion, reconstruction of the renal arteries in patients with declining renal function and renal artery stenosis or occlusion can save renal function such that dialysis may be avoided in most cases.
本研究的目的是评估手术治疗对肾功能受损的肾动脉狭窄患者的疗效。研究设计为一项有随访的回顾性调查。研究对象为1980年至1990年间在里格霍斯医院接受手术的42例此类患者。术前及随访时评估肾功能和血压状况。围手术期死亡率为5%(n = 2),发病率为21%(n = 9)。出院时,38例患者(90%)的肾功能得以维持,其中包括3例手术时无尿且已接受长达28天透析的患者。术后随访时,23例患者仍然存活,中位随访时间为66个月。累积五年生存率为62%,显著低于性别和年龄匹配人群。11例患者在随访期间出现终末期肾功能不全。五年后肾功能累积保留率为77%。总之,对于肾功能下降且存在肾动脉狭窄或闭塞的患者,肾动脉重建可挽救肾功能,多数情况下可避免透析。