Iwagaki H, Hizuta A, Iwadou H, Perdomo J A, Tanaka N, Orita K
First Department of Surgery, Okayama University Medical School, Japan.
Acta Med Okayama. 1994 Aug;48(4):225-6. doi: 10.18926/AMO/31094.
In this study, we investigated serum-soluble interleukin-2 receptor (sIL-2r) and neopterin (NPT) levels in five patients with severe postoperative infections. A total of 25 synchronous determinations of sIL-2r and NPT were performed. A marked increase in sIL-2r and NPT levels was observed, and the increase in sIL-2r was significantly correlated to that of NPT which is a marker of macrophage activity. These results suggest that macrophages are involved in the stimulation of sIL-2r release, representing a potentially negative biological effect. The results indicate that sIL-2r may be a useful indicator of the efficacy of antibiotics and of prognosis.
在本研究中，我们调查了5例严重术后感染患者的血清可溶性白细胞介素-2受体（sIL-2r）和新蝶呤（NPT）水平。共进行了25次sIL-2r和NPT的同步测定。观察到sIL-2r和NPT水平显著升高，且sIL-2r的升高与作为巨噬细胞活性标志物的NPT的升高显著相关。这些结果表明巨噬细胞参与了sIL-2r释放的刺激，代表了一种潜在的负面生物学效应。结果表明，sIL-2r可能是抗生素疗效和预后的有用指标。
