Freyschuss U, Melcher A
Scand J Clin Lab Invest. 1976 May;36(3):221-9.
The relationship of repiratory sinus arrhythmia (RSA) to the accompanying oscillations of cardiovascular pressures has been studied in five healthy subjects. Tidal volumes (VT) of 1.0, 1.5, and 2.0 1 at a breathing rate of 6 c-min(-1) were used as reference. With identical VT, oesophageal pressure was varied by negative inspiratory pressure (NIP) and intermittent positive-pressure ventilation (IPPV). Compared with control, NIP with 1.01 significantly increased RSA, the oscillations of brachial artery pressures (PBA), and the net filling pressures of the ventricles. IPPV did not significantly change the variations of PBA but reduced RSA and the repiratory variations of the right ventricular end-diastolic net pressure. During control breathing and with NIP the acceleration of heart rate during inspiration was associated with rising PBA and rising net filling pressures of both ventricles. The results indicate that RSA may be elicited by cardiovascular reflexes due to changes in venous filling of the heart rather than by the variations in systemic arterial pressure.
在五名健康受试者中研究了呼吸性窦性心律不齐（RSA）与心血管压力伴随波动之间的关系。以6次/分钟的呼吸频率，分别采用1.0、1.5和2.0升的潮气量（VT）作为参考。在潮气量相同的情况下，通过负吸气压力（NIP）和间歇性正压通气（IPPV）来改变食管压力。与对照组相比，1.0升潮气量时的NIP显著增加了RSA、肱动脉压力（PBA）的波动以及心室的净充盈压力。IPPV并没有显著改变PBA的变化，但降低了RSA以及右心室舒张末期净压力的呼吸变化。在对照呼吸和NIP期间，吸气时心率的加快与PBA升高以及两个心室净充盈压力升高有关。结果表明，RSA可能是由心脏静脉充盈变化引起的心血管反射所致，而非全身动脉压的变化。
