Hendrie H C, Hall K S, Hui S, Unverzagt F W, Yu C E, Lahiri D K, Sahota A, Farlow M, Musick B, Class C A
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-5111.
Ann Neurol. 1995 Jan;37(1):118-20. doi: 10.1002/ana.410370123.
As part of a community-based study of Alzheimer's disease (AD) in the African-American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The epsilon 4 allele of Apo E was strongly associated with AD in this population sample. The epsilon 4 allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (p = 0.01). This study extends the association of Apo E-epsilon 4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.
作为一项针对65岁及以上非裔美国人社区阿尔茨海默病（AD）研究的一部分，我们测定了85名受试者（31名AD患者和54名对照）的载脂蛋白E（Apo E）基因型。在该人群样本中，Apo E的ε4等位基因与AD密切相关。AD患者中ε4等位基因频率为40.3%，而对照组为13.9%；22.6%的AD患者为该等位基因纯合子，对照组为3.7%（p = 0.01）。本研究将Apo E-ε4与AD的关联扩展至非白人人群，并进一步证明所观察到的等位基因关联具有生物学相关性。
