Boehm F H, Hodge S J, Shaffer F H
South Med J. 1976 Jul;69(7):905-7. doi: 10.1097/00007611-197607000-00032.
The effectiveness of orally administered prostaglandin E2 in inducing labor was studied in 60 patients with uncomplicated, full-term pregnancies, using three dosage schedules. Although 40 patients did deliver, 11 patients' amniotic membranes ruptured at a time considered by the investigators to introduce an undesired variable in attempting to evaluate the drug. Twenty (33%) failed to deliver despite adequate Bishop scores. Side effects were noted in 45% of patients. No significant advantage for induction of labor occurred with the three dosage schedules used.
采用三种剂量方案，对60例无并发症的足月妊娠患者研究了口服前列腺素E2引产的有效性。尽管40例患者确实分娩，但有11例患者的胎膜在研究人员认为会在评估药物时引入不良变量的时间破裂。20例（33%）患者尽管Bishop评分足够但仍未分娩。45%的患者出现了副作用。所采用的三种剂量方案在引产方面没有显著优势。
