Majeed S K
Huntingdon Research Centre, Pathology Department, Cambridgeshire, UK.
Arzneimittelforschung. 1994 Oct;44(10):1170-3.
A survey on the distribution of mast cells in mice was carried out. Mast cells were present in abundance in tongue and to a lesser extent in sciatic nerve. Fewer numbers of mast cells were seen in lymph nodes, e.g. cervical, pararenal and iliac. Mast cells were not common in mesenteric lymph nodes in contrast to rats. Mast cells appeared to be widely distributed in different organs, e.g. salivary gland, cervix, vagina, uterus, epididymides, skeletal, muscle, ovaries, prostate, seminal vesicles, harderian glands, skin, adipose tissue, preputial gland, tail, urinary bladder, trachea, thymus and gall bladder. Mast cells were very few in heart, liver, bone marrow and lungs and generally fewer than in rats. Mast cells were very rare in spleen and adrenals. Scattered individual mast cells were occasionally seen in submucosa and serosa of stomach, oesophagus, small and large intestine. Mast cells were not seen in kidney, pituitary, testes, bone, spinal cord, brain, optic nerve and eyes. In lymph nodes mast cells appeared mainly in medullary sinusoids. There was no clear evidence of a difference between numbers of mast cells in animals of different age or sex. There was evidence of increased numbers of mast cells in inflammatory lesions and in cases of malignant tumours such as lymphomas. Presence of mast cells is incidental and is not indicative of any abnormalities.
对小鼠体内肥大细胞的分布进行了一项调查。肥大细胞在舌部大量存在，在坐骨神经中的数量较少。在淋巴结中，如颈部、肾旁和髂部淋巴结，可见到的肥大细胞数量较少。与大鼠不同，肥大细胞在肠系膜淋巴结中并不常见。肥大细胞似乎广泛分布于不同器官，如唾液腺、子宫颈、阴道、子宫、附睾、骨骼肌、卵巢、前列腺、精囊、哈德氏腺、皮肤、脂肪组织、包皮腺、尾巴、膀胱、气管、胸腺和胆囊。肥大细胞在心脏、肝脏、骨髓和肺中非常少，且一般比在大鼠体内的数量少。肥大细胞在脾脏和肾上腺中非常罕见。在胃、食管、小肠和大肠的黏膜下层和浆膜层偶尔可见散在的单个肥大细胞。在肾脏、垂体、睾丸、骨骼、脊髓、脑、视神经和眼睛中未见到肥大细胞。在淋巴结中，肥大细胞主要出现在髓质窦状隙中。没有明确证据表明不同年龄或性别的动物体内肥大细胞数量存在差异。有证据表明，在炎症病变以及淋巴瘤等恶性肿瘤病例中，肥大细胞数量会增加。肥大细胞的存在是偶然的，并不表明存在任何异常。
